Hemodynamic effects are simplified qualitative estimates based on typical neonatal use and may vary by dose and clinical context. Arrow magnitude reflects general tendencies within each domain, they are not quantitative comparisons between drugs or across domains.
| Drug | Dose | Tropies | Afterload | |||||
|---|---|---|---|---|---|---|---|---|
| Name | Start | Max | Ino | Chrono | Lusi | SVR | PVR | |
| Dopamine µg/kg/min |
2 | 10 | ↑ | ↑↑ | =/↑ | =/↑ | ↑↑ | |
| 10 | 20 | ↑ | ↑↑↑ | ↓ | ↑↑ | ↑↑↑ | ||
| Dobutamine µg/kg/min |
5 | 15 | ↑↑↑ | ↑↑ | ↑↑ | =/↓ | =/↓ | |
| Epinephrine µg/kg/min |
0.02 | 0.1 | ↑↑ | ↑↑ | =/↑ | ↑ | =/↓ | |
| 0.1 | 0.5 | ↑↑ | ↑↑↑ | ↓ | ↑↑↑ | ↑↑ | ||
| Milrinone µg/kg/min |
0.2 | 0.75 | ↑↑ | ↑ | ↑ | ↓↓↓ | ↓↓ | |
| Norepinephrine µg/kg/min |
0.05 | 0.5 | ↑↑ | ↑ | =/↑ | ↑↑↑ | ↑↑ | |
| Vasopressina mU/kg/min |
0.1 | 1 | = | =/↓ | = | ↑↑↑ | =/↓ | |
| Hydrocortisoneb mg/kg/day |
2 | 4 | = | = | = | ↑↑ | = | |
|
aAntidiuretic that may cause water retention. Caution in oliguric/anuric patients. Serial sodium levels recommended at least q6 hours.
bHydrocortisone dosing frequency divided q6-12 hr. Higher doses not shown to be superior in extremely preterm infants. |
||||||||